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Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.

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While the product has been reformulated and enhanced in its.Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.

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Trade names include Kamagra ( Ajanta Pharma ), Silagra ( Cipla ), Edegra ( Sun Pharmaceutical ), Penegra ( Zydus Cadila ), and Zenegra ( Alkem Laboratories ).Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate.

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Caution is advised in those who have cardiovascular disease.

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Also it is used to treat prostate cancer and benign prostatic hyperplasia.Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.

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Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).Medications used in the management of pulmonary arterial hypertension ( B01, C02 ).