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It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).

Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat.The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.

The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.

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The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse).

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Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

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This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.

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Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).

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Cost of viagra 50mg generic uk sale Sildenafil pfizer price in pakistan, Sildenafil sandoz 100 mg kokemuksia.Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).

Buy Teva Sildenafil Citrate.,50mg,for,sale. safe online pharmacy viagra. retail viagra price.Medication interaksi obat sildenafil. sildenafil 50mg viagra preis price of.Caution is advised in those who have cardiovascular disease.Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.