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It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease ).

Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat.The patent on Revatio (indicated for pulmonary arterial hypertension rather than erectile dysfunction) expired in late 2012.

The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.

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The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse).

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Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

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Cost of viagra 50mg generic uk sale Sildenafil pfizer price in pakistan, Sildenafil sandoz 100 mg kokemuksia.Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.Psychostimulants (e.g., amphetamines, cocaine, methylphenidate ).

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